- GTPase KRas-GNP tethered to a lipid-bilayer
- Pteridine Reductase
- E. Coli thymidylate synthase
- bisindolylmaleimide 2 to protein kinase
- PIM1 with LY333531
- DNA-anthracycline complexes
- epidoxorubicin-formaldehyde virtual crosslink of DNA
- Thrombin with inhibitors
- bleomycin-binding protein
- RAR and RXR ligand-binding domains
- penicillin V acylase
NMR data-driven model of GTPase KRas-GNP tethered to a lipid-bilayer nanodisc
Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
Lipid binding protein
Crystal Structure of Inhibitor Complex of Putative Pteridine Reductase 2 (PTR2)
Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor.
E. Coli thymidylate synthase in complex with methotrexate (MTX) and 2′-deoxyuridine 5′-monophosphate (DUMP)
Discovery of Thymidylate Synthase Inhibitors Using Flexible Docking and an Empirically Tuned Scoring Function
Dual binding mode of bisindolylmaleimide 2 to protein kinase A (PKA)
The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A.
Crystal structure of the human PIM1 in complex with LY333531
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Diversity of water ring size at DNA interfaces: hydration and dynamics of DNA-anthracycline complexes
Water ring structure at DNA interfaces: hydration and dynamics of DNA-anthracycline complexes.
Crystal structure of epidoxorubicin-formaldehyde virtual crosslink of DNA
Crystal structure of epidoxorubicin-formaldehyde virtual crosslink of DNA and evidence for its formation in human breast-cancer cells.
Thrombin with inhibitors
Bound structures of novel P3-P1′ beta-strand mimetic inhibitors of thrombin.
HYDROLASE / HYDROLASE INHIBITOR
Crystal structure of bleomycin-binding protein
The 1.6-A crystal structure of the copper(II)-bound bleomycin complexed with the bleomycin-binding protein from bleomycin-producing Streptomyces verticillus.
Human cyclophilin a complexed with 2-THR cyclosporin
X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A.
Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains
Hormone/growth Factor Receptor
Structure of truncated mutant CYS1GLY of penicillin V acylase from bacillus sphaericus co-crystallized with penicillin V
Studies on the catalysis and post translational processing of penicillin V acylase